Tissue microdissection and molecular diagnosis
نویسندگان
چکیده
منابع مشابه
Microdissection of tissue sections: application to the molecular genetic characterisation of premalignant lesions.
The characterisation of the early molecular genetic events of tumor development depends on the selective procurement of histopathologically defined small cell populations from premalignant tissue. In order to obtain high-quality DNA, mRNA and proteins from these small tissue samples and even from single cells, tissue microdissection is one of the most useful techniques, becoming increasingly im...
متن کاملTissue rotation chamber for electrophysiology, microinjection, and microdissection.
To generate complete 3-D maps of extracellular ion current patterns around insect ovarioles without removing the sample and chamber from the recording equipment, it was necessary to design a chamber permitting complete rotation of the tissue. While suction pipets have been used in previous studies to orient the tissue (1), their use can significantly disturb extracellular ionic gradients if an ...
متن کاملLaser scanning microdissection - Advantages and pitfalls in forensic diagnosis
S. Costa , L. Cainé, M.J. Porto and P. Correia-de-Sá* 1 Laboratório de Farmacologia e Neurobiologia – Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Portugal 2 Department of Legal Medicine and Forensic Sciences, Faculty of Medicine, University of Porto, Portugal 3 National Institute of Legal Med...
متن کاملMolecular Diagnosis of Familial Hypercholesterolemia
Abstract Background and objectives: Familial hypercholesterolemia (FH) is an autosomal disorder characterized by increased levels of total cholesterol and low density lipoprotein cholesterol. The FH clinical phenotype has been associated with increased risk of coronary heart disease and premature death. The mutation in LDLR gene in most cases is responsible for FH phenotype. Furthermore, other ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Juntendo Medical Journal
سال: 2001
ISSN: 0022-6769,2188-2134
DOI: 10.14789/pjmj.46.416